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You are watching: How does temperature affect the rate of dissolving

StatPearls . Treasure Island (FL): StatPearls Publishing; 2021 Jan-.



Dissolution <1><2><3>

Dissolution is the process where a solute in gaseous, liquid, or solid step dissolves in a solvent to form a solution.


Solubility is the best concentration that a solute that have the right to dissolve in a solvent in ~ a provided temperature. At the preferably concentration the solute, the systems is stated to be saturated. The units of solubility have the right to be provided in mol/L or g/L.

Factors that affect solubility include: 



The price of dissolution is represented by the Noyes-Whitney equation: dm/dt = D*A*(Cs - C)/h




Effect of temperature top top liquid and solid solutes

As temperature increases, the solubility the a solid or liquid can fluctuate depending on whether the dissolved reaction is exothermic or endothermic.

Increasing solubility with increasing temperature

In endothermic dissolved reactions, the net power from breaking and forming bonds results in heat power being absorbed into the device as the solute dissolves. As soon as the temperature that the device increases, additional head energy is introduced into the system.
So follow to Le Chatelier’s Principle, the mechanism will readjust to this boost in the warm by promoting the dissolution reaction to absorb the added heat energy. Raising the temperature will thus increase the solubility of the solute.
An example of a solute whose solubility rises with greater temperature is ammonium nitrate, which deserve to be provided in first-aid cold packs. Ammonium nitrate dissolve in solution is one endothermic reaction. As the ammonium nitrate dissolves, heat power is took in from the setting causing the surrounding setting to feel cold.
In exothermic reactions, heat power is released as soon as the solute dissolves in a solution. Boosting temperature introduces more heat into the system. Complying with Le Chatelier’s Principle, the system will change to this excess heat power by inhibiting the dissolution reaction. Boosting temperature, therefore, to reduce the solubility the the solute. 
An example of a solute the decreases in solubility with enhancing temperature is calcium hydroxide, which deserve to be offered to treat chemical burns and also as one antacid.

Effect of temperature ~ above gas solutes

In general, heat power is released together gas disappear in solution, an interpretation the dissolution reaction is exothermic. As such, a gas becomes less soluble as pleasant increases.

Increasing temperature outcomes in raised kinetic energy. Gas molecules through greater kinetic energy move an ext rapidly causing the intermolecular bonds in between the gas solute and also solvent breaking. 

Pressure: Henry’s law

The solubility the gas is impacted by transforms in press on the system. A gas disappear in liquids to type solutions. This results in equilibrium in the device where a ratio of gas molecule is dissolved in liquid while the rest stays in gaseous phase above the liquid.

Henry’s legislation states that: “At consistent temperature, the amount of gas that dissolves in a volume of fluid is proportional to the partial press of the gas in equilibrium through the liquid.”

Henry"s law results in the following equation: C = kP


C to represent the solubility that the gas at a particular temperature in a certain solvent
K represents Henry’s legislation constant
P to represent the partial press of the gas i.e. The pressure the gas exerts top top the device at a given volume and temperature

Hence as the push of the gas over the fluid in the system increases, the gas molecules become an ext soluble in the solvent. Likewise, if the pressure of the gas in the mechanism decreases, gas becomes much less soluble in the solvent.

Issues the Concern

Limitations that Henry’s law on gas solubility:

Only applies if the gas molecules are in equilibrium
Does not apply if there is a chemistry reaction between the solvent and also the solute


Solubility <7><8><9>

Le Chatelier’s principle:

If stressors favor pressure and also heat are applied to the equilibrium, the system will respond through adjusting to minimization the impacts of the stress.

For example, if pressure is applied to a system, the dissolution reaction will respond to minimize this stress by reducing the press in the system.

Heat of solution

Solids and also liquids form as a result of individual corpuscle being organized together through inter-particulate bonds. To kind a solution, power is forced to break the bonds in between the particles within the hard or liquid. Heat power is also required to break the binding in a solvent to insert one of the molecules into the solution. Both the these procedures are endothermic. Heat energy is released once the solute molecules kind bonds with the solvent molecules i.e. This procedure is exothermic.

Depending ~ above whether more energy is supplied to break the bonds in ~ the solute and also solvent or is exit when new bonds space formed between the solute and also solvent, the reaction as whole can be exothermic or endothermic.

If an ext energy is compelled to rest the bonds in ~ the solute and solvent than is exit when new bonds space formed in between the solute and also solvent, the reaction is thought about endothermic.
If much more energy is released when new bonds are formed in between the solute and solvent than is required to rest the bonds in ~ the solute and also solvent, the reaction is considered exothermic.

The complete amount of heat energy released indigenous or absorbed by the device = sum of warmth energy soaked up when binding are damaged – the amount of heat power released once bonds space formed

If the full amount of heat power released/absorbed native the device is higher than zero, the reaction is endothermic.
If the full amount the heat power released/absorbed from the device is less than zero, the reaction is exothermic.


Application of Henry’s Law: Decompression Sickness

Henry’s Law describes the phenomena that decompression sickness. Once scuba divers submerge us in deep water, the push of the water rises the pressure in your bodies. Nitrogen, a gas in our blood, dissolves under the boosted pressure. Nitrogen is physiologically inert, so the is not provided in organization metabolism. If the scuba diver ascends come the surface ar too quickly, the rapid autumn in pressure decreases the solubility that nitrogen, causing nitrogen bubbles to come the end of solution. The nitrogen bubbles can type painful and also potentially deadly gas embolisms.

Clinical Significance


Dissolution is important for wellness practitioners because, because that drugs come be took in and have a physiological effect in the human body, they should be in solution. Because that solid preparations, such as tablets and suppositories, the rate of dissolution affects how fast a drug is soaked up in the body.


Aqueous solubility is often thought about when formulating drugs. Poorly dissolve formulations carry out difficulties in the advancement of pharmaceuticals. Chloramphenicol, phenytoin, and digoxin space some examples. Drugs, particularly those for dental administration, may have poor aqueous solubility. This may result in low bioavailability top to poor exposure and physiologic result in the body.

Review Questions


Joshi K, Chandra A, Jain K, Talegaonkar S. Nanocrystalization: one Emerging modern technology to boost the Bioavailability the Poorly soluble Drugs. Pharm Nanotechnol. 2019;7(4):259-278.
Itai S. . Yakugaku Zasshi. 2019;139(3):419-435.
Karaźniewicz-Łada M, Bąba K, Dolatowski F, Dobrowolska A, Rakicka M. The polymorphism that statins and also its impact on your physicochemical properties. Polim Med. 2018 Jul-Dec;48(2):77-82.
Sujka M, Pankiewicz U, Kowalski R, Nowosad K, Noszczyk-Nowak A. Porous starch and also its applications in drug shipment systems. Polim Med. 2018 Jan-Jun;48(1):25-29.
Modica de Mohac L, Keating AV, de Fátima Pina M, Raimi-Abraham BT. Engineering of Nanofibrous Amorphous and Crystalline heavy Dispersions for oral Drug Delivery. Pharmaceutics. 2018 Dec 24;11(1)
Couillaud BM, Espeau P, Mignet N, Corvis Y. State that the art of pharmaceutical Solid Forms: from crystal Property issues to Nanocrystals Formulation. ChemMedChem. 2019 january 08;14(1):8-23.
Ribeiro ACF, Esteso MA. Transport Properties because that Pharmaceutical Controlled-Release Systems: A short Review that the prestige of Their examine in biological Systems. Biomolecules. 2018 Dec 17;8(4)

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